SpringerProtocols: Abstract: 4. Target Discovery and Validation in Pancreatic Cancer

4. Target Discovery and Validation in Pancreatic Cancer

By: Robert M. Beaty², Mads Gronborg^{3 4}, Jonathan R. Pollack⁵, Anirban Maitra⁵

Abstract

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Pancreatic cancer is a lethal disease and rational strategies fo gene expression, and mass spectrometric analysis of proteins, have led to identification of cellular targets with considerable potential for clinical application and patient care. These studies underscore the importance of pursuing large-scale profiling of human cancers not only for furthering our understanding of the pathogenesis of these malignancies but also for developing strategies to improve patient outcomes.

Affiliation(s): (2) Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD
(3) McKusick-Nathans Institute of Genetic Medicine, University of Southern Denmark, Odense, Denmark
(4) Departments of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
(5) Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

Book Title: Target Discovery and Validation Reviews and Protocols: Volume 1, Emerging Strategies for Targets and Biomarker Discovery

Series: Methods in Molecular Biology | Volume: 360 | Pub. Date: Oct-15-2006 | Page Range: 57-89 | DOI: 10.1385/1-59745-165-7:57

Subject: Pharmacology/Toxicology

Key Words: Bioinformatics - DNA microarrays - pancreatic cancer - proteomics - target discovery - serial analysis of gene expression - SAGE

References

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