SpringerProtocols: Abstract: 1. An Overview of C. elegans Biology

1. An Overview of C. elegans Biology

By: Kevin Strange^{4 5 6}

Abstract

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The establishment of Caenorhabditis elegans as a “model organism” began with the efforts of Sydney Brenner in the early 1960s. Brenner’s focus was to find a suitable animal model in which the tools of genetic analysis could be used to define molecular mechanisms of development and nervous system function. C. elegans provides numerous experimental advantages for such studies. These advantages include a short life cycle, production of large numbers of offspring, easy and inexpensive laboratory culture, forward and reverse genetic tractability, and a relatively simple anatomy. This chapter will provide a brief overview of C. elegans biology.

Affiliation(s): (4) Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN
(5) Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN
(6) Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN

Book Title: C. elegans: Methods and Applications

Series: Methods in Molecular Biology | Volume: 351 | Pub. Date: Aug-15-2006 | Page Range: 1-11 | DOI: 10.1385/1-59745-151-7:1

Subject: Genetics/Genomics

Key Words: Genetics - anatomy - life cycle - laboratory culture

References

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