SpringerProtocols: Abstract: 4. Mouse Morphological Phenotyping With Magnetic Resonance Imaging

4. Mouse Morphological Phenotyping With Magnetic Resonance Imaging

By: X. Josette Chen^{2 3}

Abstract

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The field of mouse phenotyping with magnetic resonance imaging (MRI) is rapidly growing, with both MRI physicists and biologists starting to use MRI to identify mouse models of human disease. The purpose of this chapter is to provide details of the animal handling necessary for routine and robust in vivo imaging with particular emphasis on multiple-mouse imaging. In addition, techniques for perfusion-fixation for postmortem imaging of specimens and whole mice are given.

Affiliation(s): (2) Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
(3) Mouse Imaging Centre, Integrative Biology, Hospital for Sick Children, Toronto, Ontario, Canada

Book Title: Magnetic Resonance Imaging: Methods and Biologic Applications

Series: Methods in Molecular Medicine | Volume: 124 | Pub. Date: Nov-01-2005 | Page Range: 103-127 | DOI: 10.1385/1-59745-010-3:103

Subject: Imaging/Radiology

Key Words: MRI - magnetic resonance imaging - mouse - phenotyping - random mutagenesis - anesthesia - mouse handling - monitoring - central nervous system - cardiac - whole-body perfusion - excised organs

References

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