SpringerProtocols: Abstract: Supercritical Fluid Extraction

Supercritical Fluid Extraction

By: Lutfun Nahar⁴, Satyajit D. Sarker⁵

Abstract

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Supercritical fluids (SCFs) are increasingly replacing organic solvents, e.g., n-hexane, dichloromethane, chloroform, and so on, that are conventionally used in industrial extraction, purification, and recrystallization operations because of regulatory and environmental pressures on hydrocarbon and ozone-depleting emissions. In natural product extraction and isolation, supercritical fluid extraction (SFE), especially that employing supercritical CO₂, has become the method of choice. Sophisticated modern technologies allow precise regulation of changes in temperature and pressure, and thus manipulation of solvating property of the SCF, which helps the extraction of natural products of a wide range of polarities. This chapter deals mainly with the application of the SFE technology in the natural product extraction and isolation, and discusses various methodologies with specific examples.

Affiliation(s): (4) School of Life Sciences, The Robert Gordon University, Aberdeen, Scotland, UK
(5) Pharmaceutical Biotechnology Research Group, School of Biomedical Sciences, University of Ulster at Coleraine, Coleraine, Northern Ireland, UK

Book Title: Natural Products Isolation

Series: Methods in Biotechnology | Volume: 20 | Pub. Date: Sep-19-2005 | Page Range: 47-76 | DOI: 10.1385/1-59259-955-9:47

Subject: Biochemistry

Key Words: Supercritical fluid extraction (SFE) - supercritical fluid (SCF) - supercritical carbon dioxide - natural products

References

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1.	Supercritical Fluid Chromatography (SFC) (2004) IsoPro International, Menlo Park, USA. Available on-line at: http://www.isopro.net/web8.htm

2.	Ramsey, E. D. (1998) Analytical Supercritical Fluid Extraction Techniques. Kluwer Academic Publishers, Dordrecht.

3.	McHugh, M. A. and Krukonis, V. J. (1994) Supercritical Fluid Extraction: Principles and Practice. 2 ed., Butterworth-Heinemann.

4.	Taylor, L. T. (1996) Supercritical Fluid Extraction, Wiley-Interscience.

5.	Mukhopadhyay, M. (2000) Natural Extracts Using Supercritical Carbon Dioxide. 1 ed., CRC Press London.

6.	Bright, F. V. and McNally, M. E. P. (1992) Supercritical Fluid Technology: Theoretical and Applied Approaches to Analytical Chemistry. American Chemical Society, Washington, DC.

7.	Bruno, T. J. and Ely, J. F. (1991) Supercritical Fluid Technology: Reviews in Modern Theory and Application. CRC Press, Boca Raton, FL.

8.	Johnston, K. P. and Penninger, J. M. L. (1989) Supercritical Fluid Science and Technology. American Chemical Society, Washington, DC.

9.	Wenclawiak, B. (1992) Analysis with Supercritical Fluids: Extraction and Chromatography. Springer-Verlag, Berlin.

10.	De Castro, M. D. L., Valcarcel, M., and Tena, M. T. (1994) Analytical supercritical fluid extraction. Springer-Verlag, Berlin.

11.	Andrews, A. T. (1990) Supercritical carbondioxide extraction of polycyclic aromatic hydrocarbons from contaminated soil. PhD thesis, Rutgers, The State University of New Jersey, Piscataway, NJ.

12.	Venkat, E. and Kothandaraman, S. (1998) Supercritical fluid methods, in Natural Products Isolation. 1st ed. (Cannell, R. J. P., ed.), Humana Press, New Jersey.

13.	Bevan, C. D. and Marshall, P. S. (1994) The use of supercritical fluids in the isolation of natural products Nat. Prod. Rep. 11, 451–466.

14.	Castioni, P., Christen, P., and Veuthey, J. L. (1995) Supercritical-fluid extraction of compounds from plant origin. Analysis 23, 95–106.

15.	Catchpole, O. J., Grey, J. B., Perry, N. B., Burgess, E. J., Redmond, W. A., and Porter, N. G. (2003) Extraction of chill, black pepper, and ginger with near critical CO₂, propane, dimethyl ether: analysis of the extracts by quantitative nuclear magnetic resonance J. Agric. Food Chem. 51, 4853–4860.

16.	Ferreira, S. R. S. and Meireles, M. A. A. (2002) Modelling the supercritical fluid extraction of black pepper (Piper nigrum L) essential oil. J. Food Eng. 54, 263–269.

17.	Ferreira, S. R. S., Nikolov, Z. L., Doraiswamy, L. K., Meireles, M. A. A., and Petenate, A. J. (1999) Supercritical fluid extraction of black pepper (Piper nigrum L) essential oil. J. Supercrit. Fluids 14, 235–245.

18.	Sovova, H., Jez, J., Bartlova, M., and Stastova, J. (1995) Supercritical carbon dioxide extraction of black pepper J. Supercrit. Fluids 8, 295–301.

19.	Uquiche, E., del Valle, J. M., and Ortiz, J. (2004) Supercritical carbon dioxide extraction of red pepper (Capsicum annuum L) oleoresin. J. Food Eng. 65, 55–66.

20.	Rodrigues, M. R. A., Krause, L. C., Caramao, E. B., Dos Santos, J. G., Dariva, C., and De Oliveira, J. V. (2004) Chemical composition and extraction yield of the extract of Origanum vulgare obtained from sub-and supercritical CO₂. J. Agric. Food Chem. 52, 3042–3047.

21.	Salgin, U., Calimli, A., and Uysal, B. Z. (2004) Supercritical fluid extraction of jojoba oil J. Am. Oil Chem. Soc. 81, 293–296.

22.	Louli, V., Folas, G., Voutsas, E., and Magoulas, K. (2004) Extraction of parsley seed oil by supercritical CO₂ J. Supercrit. Fluids 30, 163–174.

23.	Sonsuzer, S., Sahin, S., and Yilmaz, L. (2004) Optimization of supercritical CO₂ extraction of Thymbra spicata oil. J. Supercrit. Fluids 30, 189–199.

24.	Perva-Uzunalic, A., Skerget, M., Weinreich, B., and Knez, Z. (2004) Extraction of chilli pepper (var. Byedige) with supercritical CO₂: effect of pressure and temperature on capsaicinoid and colour extraction efficiency. Food Chem. 87, 51–58.

25.	Duarte, C., Moldao-Martins, M., Gouveia, A. F., da Costa, S. B., Leitao, A. E., and Bernardo-Gil, M. G. (2004) Supercritical fluid extraction of red pepper (Capsicum frutescens L). J. Supercrit. Fluids 30, 155–161.

26.	Palenzuela, B., Arce, L., Macho, A., Munoz, E., Rios, A., and Valcarcel, M. (2004) Bioguided extraction of polyphenols from grape marc by using an alternative supercritical-fluid extraction method based on a liquid solvent trap. Anal. Bioanal. Chem. 378, 2021–2027.

27.	Martino, K. G. and Guyer, D. (2004) Supercritical fluid extraction of quercetin from onion skins J. Food Process Eng. 27, 17–28.

28.	Luengthanaphol, S., Mongkholkhajornsilp, D., Douglas, S., Douglas, P. L., Pengsopa, L., and Pongamphai, S. (2004) Extraction of antioxidants from sweet Thai tamarind seed coat—preliminary experiments J. Food Eng. 63, 247–252.

29.	Chiu, K.-L., Cheng, Y.-C., Chen, J.-H., Chang, C.J., and Yang, P.-W. (2002) Supercritical fluids extraction of Ginkgo ginkgolides and flavonoids. J. Supercrit. Fluids 24, 77–87.

30.	van Beek T. A. (2002) Chemical analysis of Ginkgo biloba leaves and extracts J Chromatography A 967, 21–55.

31.	Rompp, H., Seger, C., Kaiser, C. S., Haslinger, E., and Schmidt, P. C. (2004) Enrichment of hyperforin from St John’s Wort (Hypericum perforatum) by pilot-scale supercritical carbon dioxide extraction. Eur. J. Pharm. Sci. 21, 443–451.

32.	Smith, R. M. (1996) Supercritical fluid extraction of natural products. LC-GC International, 8–15.

33.	Smith, R. M. and Burford, M. D. (1992) Supercritical fluid extraction and gas-chromatographic determination of the sesquiterpene lactone partheno-lide in the medicinal herb feverfew (Tanacetum parthenium) J. Chromatography 627, 255–261.

34.	Čretnik, L., Škerget, M., and Knez, Z. (2005) Separation of parthenolide from feverfew: performance of conventional and high-pressure extraction techniques. Separation Purification Technol 41, 13–20.

35.	Jennings, D. W., Deutsch, H. M., Zalkow, L. H., and Teja, A. S. (1992) Supercritical extraction of taxol from the bark of Taxus brevifolia J. Super-crit. Fluids 5, 1–6.

36.	Pascual-Marti, M. C., Salvador, A., Chafer, A., and Berna, A. (2001) Supercritical fluid extraction of resveratrol from grape skin of Vitis vinifera and determination by HPLC Talanta 54, 735–740.

37.	Simandi, B., Kristo, S. T., Kery, A., Selmeczi, L. K., Kmecz, I., and Kemeny, S. (2002) Supercritical fluid extraction of dandelion leaves. J. Supercrit. Fluids 23, 135–142.

38.	te Bokkel (1990). Supercritical carbon dioxide extraction of cyclosporine from the fungus Beauvaria nivea. Ph.D. thesis, The University of Western Ontario, Canada.

39.	Bottalico, A., Logrieco, A., and Visconti, A. (1989) Taxonomy and Pathogenicity. Elsevier, New York, pp. 85–119.

40.	Ambrosino, P., Galvano, F., Fogliano, V., Logrieco, A., Fresa, R., and Ritieni, A. (2004) Supercritical fluid extraction of beauvericin from maize Talanta 62, 523–530.

41.	Lim, G.-B., Lee, S.-Y., Lee, E.-K., Haam, S.-J., and Kim, W.-S. (2002) Separation of astaxanthin from red yeast Phaffia rhodozyma by supercritical carbon dioxide extraction Biochem. Eng. J. 11, 181–187.

42.	Ashraf-Khorassani, M. and Taylor, L. T. (2004) Sequential fractionation of grape seeds into oils, polyphenols, and procyanidins via a single system employing CO₂ based fluids J. Agric. Food Chem. 52, 2440–2444.

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