SpringerProtocols: Abstract: Surface-Functionalized Nanoparticles for Controlled Drug Delivery

Surface-Functionalized Nanoparticles for Controlled Drug Delivery

By: Sung-Wook Choi², Woo-Sik Kim², Jung-Hyun Kim³

Abstract

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Nanoparticles have been extensively investigated in drug-delivery systems. Especially, the effectiveness of the surface-functionalized nanoparticles, which consist of copolymers with functional molecules, is well demonstrated. This chapter describes the complete technique for the preparation of surface-functionalized nanoparticles. Tetracycline with an affinity to bone was chosen as a model material for surface functionalization. There are two steps for the preparation of tetracycline-modified nanoparticles. The first step is the conjugation of poly(D,L-lactide-coglycolic acid) with tetracycline via carbodiimide chemistry and is the most often employed. Three kinds of techniques—the emulsification-diffusion method, nanoprecipitation, and the dialysis method—are used for nanoparticle formation of the resulting copolymer. Prepared nanoparticles having a size <200 nm and a hydrophilic surface layer can be applied for bone-specific drug delivery.

Affiliation(s): (2) Division of Chemical Engineering and Biotechnology, Yonsei University, Seoul, Korea
(3) Nanosphere Process and Technology Laboratory, Yonsei University, Seoul, Korea

Book Title: NanoBiotechnology Protocols

Series: Methods in Molecular Biology | Volume: 303 | Pub. Date: Apr-27-2005 | Page Range: 121-131 | DOI: 10.1385/1-59259-901-X:121

Subject: Biotechnology

Key Words: Surface-functionalized nanoparticles - carbodiimide chemistry poly(D,L-lactide-co-glycolic acid) - tetracycline - emulsification-diffusion method - nanoprecipitation method - dialysis method - bone-specific drug delivery

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