SpringerProtocols: Abstract: 6. The Mammalian Cell Cycle: An Overview

6. The Mammalian Cell Cycle: An Overview

By: Jane V. Harper, Gavin Brooks

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In recent years, we have witnessed major advances in our understanding of the mammalian cell cycle and how it is regulated. Normal mammalian cellular proliferation is tightly regulated at each phase of the cell cycle by the activation and deactivation of a series of proteins that constitute the cell cycle machinery. This review article describes the various phases of the mammalian cell cycle and focuses on the cell cycle regulatory molecules that act at each stage to ensure normal cellular progression.

Book Title: Cell Cycle Control: Mechanisms and Protocols

Series: Methods in Molecular Biology | Volume: 296 | Pub. Date: Dec-01-2004 | Page Range: 113-153 | DOI: 10.1385/1-59259-857-9:113

Subject: Cell Biology

Key Words: 14-3-3 - anaphase-promoting complex - CDC25 - cyclins - cyclin-dependent kinases (Cdks) - Cdk inhibitors - cytokinesis - DNA replication - E2F transcription factors - endoreduplication - MAP kinase - pocket proteins - SCF ubiquitin ligases

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