SpringerProtocols: Abstract: 3. The C. elegans Cell Cycle: Overview of Molecules and Mechanisms

3. The C. elegans Cell Cycle: Overview of Molecules and Mechanisms

By: Sander van den Heuvel

Abstract

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The nematode C. elegans provides an animal model that allows for genetic dissection of cell cycle regulation in the context of development. Processes such as progression through meiotic prophase, spindle function, chromosome segregation, and cytokinesis are attractive topics to study in the worm, because of their relative visibility and susceptibility to RNA interference. In addition, the reproducible cell lineage greatly helps the identification and characterization of mutants that affect cell cycle entry or exit during larval development. This chapter looks at cell division as an integral part of C. elegans development, describes how it can be studied in the worm and summarizes some of the conserved cell cycle components described to date.

Book Title: Cell Cycle Control: Mechanisms and Protocols

Series: Methods in Molecular Biology | Volume: 296 | Pub. Date: Dec-01-2004 | Page Range: 51-67 | DOI: 10.1385/1-59259-857-9:051

Subject: Cell Biology

Key Words: C. elegans; development - meiosis - G1 control - chromosome segregation - cytokinesis - cyclin - dependent kinases - lin-35 Rb

References

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