SpringerProtocols: Abstract: Mapping the Systemic Lupus Erythematosus Susceptibility Genes

Mapping the Systemic Lupus Erythematosus Susceptibility Genes

By: Swapan K. Nath², Jennifer A. Kelly², John B. Harley^{2 3 4}, R. Hal Scofield^{2 3 4}

Abstract

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Systemic lupus erythematosus (SLE) is a prototype systemic, autoimmune inflammatory disease that can involve virtually any organ or tissue type. The disease has a strong familial tendency but, like most human illness, has a complex pattern of inheritance that is consistent with multiple susceptibility genes as well as environmental risk factors. Association studies have been performed, especially for the major histocompatibility complex on chromosome 6 and for various complement components. Several large familial studies have begun to report results for genetic linkage. Linkage has been established for many genetic intervals. SLE is a complex clinical illness, and investigation of the genetics of the illness based on clinical manifestations revealed linkages not found without consideration of the phenotype of the disease.

Affiliation(s): (2) Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
(3) Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
(4) Department of Veterans Affairs Medical Center, Oklahoma City, OK

Book Title: Autoimmunity: Methods and Protocols

Series: Methods in Molecular Medicine | Volume: 102 | Pub. Date: Aug-01-2004 | Page Range: 11-29 | DOI: 10.1385/1-59259-805-6:011

Subject: Immunology

Key Words: Autoantibodies - autoantigens - complement - genetic association - genetic linkage - HLA - systemic lupus erythematosus

References

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