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Xenografting and Harvesting Human Ductal Pancreatic Adenocarcinomas for DNA Analysis
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Xenotransplantation (xenografting) of primary cancers or cancer cell lines into immunodeficient mice is a commonly used technique
to assess tumor growth in response to a variety of experimental agents. When primary pancreatic cancers are xenografted, cancer
cells proliferate in the mouse, but the human stroma does not. This growth pattern enables facile genetic analysis of cancer
genetics profiles without the contamination of admixed stromal cells typical of primary cancers.
Affiliation(s): (2) Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD
(3) Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD
(4) The Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, MD
(3) Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD
(4) The Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, MD
Book Title: Pancreatic Cancer: Methods and Protocols
Series: Methods in Molecular Medicine | Volume: 103 | Pub. Date: Nov-12-2004 | Page Range: 103-111 | DOI: 10.1385/1-59259-780-7:103
Subject: Cancer Research
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