SpringerProtocols: Abstract: Modeling Diabetic Sensory Neuropathy in Rats

Modeling Diabetic Sensory Neuropathy in Rats

By: Nigel A. Calcutt²

Abstract

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The procedures to induce insulin-deficient diabetes in rats using streptozotocin are described along with a number of insulin treatment regimes that can be used to maintain these animals at different degrees of glycemia for periods of weeks to months. Streptozotocin-diabetic rats develop tactile allodynia, hyperalgesia following paw formalin injection and abnormal responses to thermal stimulation and the detailed methods used to evaluate these behavioral indices of abnormal sensory function are provided.

Affiliation(s): (2) Department of Pathology, University of California San Diego, La Jolla, CA

Book Title: Pain Research: Methods and Protocols

Series: Methods in Molecular Medicine | Volume: 99 | Pub. Date: May-15-2004 | Page Range: 55-65 | DOI: 10.1385/1-59259-770-X:225

Subject: Molecular Medicine

Key Words: Diabetes - streptozotocin - neuropathy - tactile allodynia - formalin test - thermal hyperalgesia - nociception - neuropathic pain - rat

References

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