SpringerProtocols: Abstract: Drug Resistance: The Clinical Perspective

Drug Resistance: The Clinical Perspective

By: D. Alan Anthoney³, Stanley B. Kaye³

Abstract

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There are very few tumor types in which the use of chemotherapy can bring about prolonged survival, and possibly cure, for individual patients. The most common reason for this is the development of drug resistance within tumor cells. The laboratory study of resistance to anticancer drugs has resulted in the discovery of numerous mechanisms present within tumor cells that act to reduce their cytotoxic effects. However, the failure to translate this basic laboratory research into improved clinical outcome for patients remains one of the most pressing problems in contemporary cancer research.

Affiliation(s): (3) CRC Department of Medical Oncology, Beatson Laboratories, University of Glasgow, Glasgow, UK

Book Title: Cytotoxic Drug Resistance Mechanisms

Series: Methods in Molecular Medicine | Volume: 28 | Pub. Date: Apr-05-1999 | Page Range: 1-15 | DOI: 10.1385/1-59259-687-8:1

Subject: Cancer Research

References

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