Springer Protocols: Abstract: Quantitative Light Microscopic Autoradiography of α2-Adrenergic Radioligand Binding Sites

Quantitative Light Microscopic Autoradiography of α2-Adrenergic Radioligand Binding Sites

By: Ursula H. Winzer-Serhan², Frances M. Leslie³

Abstract

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Adrenergic receptors (ARs) belong to the family of G-protein-coupled receptors and can be classified into three subfamilies, with each one having at least three distinct subtypes (1). Although all three subfamilies have similar affinity for the endogenous ligands norepinephrine and epinephrine, they can be characterized by their different pharmacological profiles, which was the first evidence for receptor heterogeneity, prior to the molecular cloning of nine different adrenergic receptor genes (2).

Affiliation(s): (2) Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
(3) Department of Pharmacology, College of Medicine, University of California, Irvine, CA

Book Title: Adrenergic Receptor Protocols

Series: Methods in Molecular Biology | Volume: 126 | Pub. Date: Nov-05-1999 | Page Range: 507-517 | DOI: 10.1385/1-59259-684-3:507

Subject: Neuroscience

References

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