SpringerProtocols: Abstract: Chiral Separation Principles: An Introduction

Chiral Separation Principles: An Introduction

By: Gerald GÃ¼bitz², Martin G. Schmid²

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The development of methods for chiral separation on an analytical as well as on a preparative scale has attracted great attention during the past two decades. Chromatographic methods such as gas chromatography (GC) (1), high-performance liquid chromatography (HPLC) (2–6), supercritical fluid chromatography (SFC) (7–9), and thin-layer chromatography (TLC) (10–13) have been developed using different chiral separation principles. More recently, capillary electrophoresis (CE) (14–21) and capillary electrochromatography (CEC) (22–25) have been shown to be powerful alternatives to chromatographic methods. Several separation principles successfully used in HPLC have been transferred to CE and CEC. For the separation of enantiomers on a preparative scale, LC has become increasingly attractive.

Affiliation(s): (2) Institute of Pharmaceutical Chemistry and Pharmaceutical Technology, Karl-Franzens University, Graz, Austria

Book Title: Chiral Separations: Methods and Protocols

Series: Methods in Molecular Biology | Volume: 243 | Pub. Date: Dec-15-2003 | Page Range: 1-28 | DOI: 10.1385/1-59259-648-7:001

Subject: Biochemistry

References

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