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Nonreplicating DNA Viral Vectors for Suicide Gene Therapy: The Adenoviral Vectors
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Nonreplicative DNA viral vectors (i.e., adenovirus, herpes simplex virus, adeno-associated virus) have been widely used for
suicide gene therapy against cancer because their strong and temporary expression of the transgene fit this purpose. Particularly,
nonreplicating “adenoviral” vectors have been used in the largest number of clinical trials among all viral vectors. Thus,
this chapter covers the adenovirus type 5-based nonreplicative vector.
Affiliation(s): (2) Division of Human Gene Therapy, Departments of Medicine, Pathology, and Surgery, University of Alabama at Birmingham, AL
(3) the Gene Therapy Center, University of Alabama at Birmingham, AL
(3) the Gene Therapy Center, University of Alabama at Birmingham, AL
Book Title: Suicide Gene Therapy: Methods and Reviews
Series: Methods in Molecular Medicine | Volume: 90 | Pub. Date: Nov-04-2003 | Page Range: 61-70 | DOI: 10.1385/1-59259-429-8:61
Subject: Genetics/Genomics
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