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10. Isolation and Osteogenic Differentiation of Bone-Marrow Progenitor Cells for Application in Tissue Engineering
| Abstract |
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One of the most widely studied bone-tissue engineering approaches involves the seeding and extended in vitro culturing of
cells within a biodegradable scaffold prior to implantation. The bioresorbable scaffold must be biocompatible and porous in
order to facilitate rapid vascularization and growth of newly formed tissue (1–8). During the in vitro culture period, the seeded cells proliferate and secrete tissue-specific extracellular matrix (ECM).
The selection of the scaffold material, which should exhibit an adequate three-dimensional (3D) porous structure, is a primary
consideration in matrix- and cell-based bone-tissue engineering strategies (9).
Affiliation(s): (3) Department of Polymer Engineering, University of Minho, Guimarães, Portugal
(4) Biomaterials, Biodegradables, and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, Braga, Portugal
(4) Biomaterials, Biodegradables, and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, Braga, Portugal
Book Title: Biopolymer Methods in Tissue Engineering
Series: Methods in Molecular Biology | Volume: 238 | Pub. Date: Nov-17-2003 | Page Range: 123-129 | DOI: 10.1385/1-59259-428-X:123
Subject: Biochemistry
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