SpringerProtocols: Abstract: Hematopoietic Stem and Progenitor Cells

Hematopoietic Stem and Progenitor Cells

By: Robert E. Donahue², Irvin S. Y. Chen³

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There has been much effort in isolating hematopoietic stem cells (HSC) and some confusion within the literature on what even a HSC is, with some investigators using the term inappropriately (1). A HSC is a cell capable of both self-renewal and of deriving progeny of all hematopoietic cell lineages, that is, a single HSC can regenerate erythroid, myeloid, megakaryocytic, and lymphoid lineages in a myeloablated host. Progenitor cells, on the other hand, are cells committed to one or a few lineages having a limited capacity for self-renewal. Progenitors are the progeny of HSC.

Affiliation(s): (2) Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD
(3) UCLA AIDS Institute, School of Medicine, Los Angeles, CA

Book Title: Lentivirus Gene Engineering Protocols

Series: Methods in Molecular Biology | Volume: 229 | Pub. Date: Apr-30-2003 | Page Range: 117-130 | DOI: 10.1385/1-59259-393-3:117

Subject: Genetics/Genomics

References

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