SpringerProtocols: Abstract: Use of Tumor-Activated Hepatic Stellate Cell as a Target for the Preclinical Testing of Anti-Angiogenic Drugs Against Hepatic Tumor Development

Use of Tumor-Activated Hepatic Stellate Cell as a Target for the Preclinical Testing of Anti-Angiogenic Drugs Against Hepatic Tumor Development

By: Elvira Olaso³, Fernando Vidal-Vanaclocha³

Abstract

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The prognosis of patients with advanced liver tumors is very poor, regardless of current treatment schedules based on surgery and/or chemotherapy. Anti-angiogenic therapy represents one of the most promising target-oriented therapeutic approaches. However, because of organ-specific differentiation of liver microvasculature (1), the use of non organ-specific models of angiogenesis may not be adequate for screening candidate anti-angiogenic compounds, and only a few preclinical models that are able to provide clinically relevant therapeutic options are available.

Affiliation(s): (3) Department of Cell Biology, Basque Country University School of Medicine and Dentistry, Leioa, Spain

Book Title: Novel Anticancer Drug Protocols

Series: Methods in Molecular Medicine | Volume: 85 | Pub. Date: Mar-26-2003 | Page Range: 79-86 | DOI: 10.1385/1-59259-380-1:79

Subject: Cancer Research

References

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