SpringerProtocols: Abstract: Biochemical Endophenotypes in Personality Disorders

Biochemical Endophenotypes in Personality Disorders

By: Antonia S. New³, Larry J. Siever⁴

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Candidate gene association studies in psychiatric disorders have suffered from difficulties in replication. One strategy for overcoming this difficulty is a focus on endophenotypes. If most psychiatric disorders are polygenic and are caused by numerous genes—each contributing a small effect and conferring susceptibility to the phenotype, then it is difficult to identify the influence of each of these genetic contributions to the phenotype. A recent approach, which is the focus of this volume, is the identification of endophenotypes—components of a syndrome that may be influenced by a smaller number of genes and may be more easily associated with a genotype. Other chapters (7,9,10) cover cognitive, electrophysiologic, and neuroimaging endophenotypes. This chapter reviews promising biochemical endophenotypes, using personality disorders as a model.

Affiliation(s): (3) Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
(4) Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

Book Title: Psychiatric Genetics: Methods and Reviews

Series: Methods in Molecular Medicine | Volume: 77 | Pub. Date: Sep-10-2002 | Page Range: 199-213 | DOI: 10.1385/1-59259-348-8:199

Subject: Neuroscience

References

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