SpringerProtocols: Abstract: Genetic Association Studies: Definition of Cases and Controls

Genetic Association Studies: Definition of Cases and Controls

By: Frank Bellivier³

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The case-control association study is one of the most frequently used study designs for investigating the effect of environmental risk factors on disease pathogenesis. This study design is also now increasingly used to investigate the influence of genetic variability on disease susceptibility. This type of study has a number of theoretical advantages over linkage studies. Association studies do not require knowledge of the genetic model of the disease, and the phenotype being studied is controlled, making it possible to study homogeneous subgroups that are selected on the basis of a candidate symptom. These studies can also detect genes that contribute only a small proportion of the overall likelihood of developing the disorder, which would require prohibitively large samples for detection in linkage studies.

Affiliation(s): (3) Service de psychiatrie (Pr Rouillon), Häpital Henri Mondor, 94010 Creitel Cedex, France

Book Title: Psychiatric Genetics: Methods and Reviews

Series: Methods in Molecular Medicine | Volume: 77 | Pub. Date: Sep-10-2002 | Page Range: 127-142 | DOI: 10.1385/1-59259-348-8:127

Subject: Neuroscience

References

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