SpringerProtocols: Abstract: SNPs: Why Do We Care?

SNPs: Why Do We Care?

By: Lisa D. Brooks²

Abstract

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Single-nucleotide polymorphism (SNP) is a new term for an old concept. Geneticists have been trying for decades to find the genetic differences among individuals. Originally phenotypes were used, then protein sequence, electrophoresis, restriction fragment polymorphisms (RFLPs), and microsatellites. With recent technologies for DNA sequencing and the detection of single-base differences, we are approaching the time when all differences in DNA sequence among individuals can be found. The next challenge is to relate these genetic differences to phenotypes such as disease risk and response to therapies.

Affiliation(s): (2) National Human Genome Research Institute, National Institutes of Health, Bethesda, MD

Book Title: Single Nucleotide Polymorphisms: Methods and Protocols

Series: Methods in Molecular Biology | Volume: 212 | Pub. Date: Oct-07-2002 | Page Range: 1-14 | DOI: 10.1385/1-59259-327-5:001

Subject: Genetics/Genomics

References

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