SpringerProtocols: Abstract: Use of cDNA Representational Difference Analysis to Identify Disease-Specific Genes in Human Atherosclerotic Plaques

Use of cDNA Representational Difference Analysis to Identify Disease-Specific Genes in Human Atherosclerotic Plaques

By: Kerry Tyson², Catherine Shanahan²

Abstract

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Changes in gene expression underlie many biological phenomena, including cellular differentiation and activation, embryonic development, and pathological processes. In recent years, much attention has been focused on the identification of genes that are differentially expressed between normal and disease states: the isolation of disease-specific genes is not only essential for our understanding of the molecular basis of pathological conditions, but may potentially highlight novel therapeutic targets.

Affiliation(s): (2) Department of Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK

Book Title: Vascular Disease: Molecular Biology and Gene Therapy Protocols

Series: Methods in Molecular Medicine | Volume: 30 | Pub. Date: Aug-01-1999 | Page Range: 83-98 | DOI: 10.1385/1-59259-247-3:83

Subject: Molecular Medicine

References

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