Construction of Microsatellite-Based, High-Resolution Genetic Maps in the Mouse
By: Paul A. Lyons2
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The mapping of genes underlying either simple mendelian or complex traits can be broken down into a number of distinct stages—initial
detection of the locus in a genome scan, determination of the most likely map location for the gene, and finally fine mapping
of the locus. A number of experimental strategies for mapping genes in experimental organisms are available and their relative
merits have been reviewed recently (1). Whatever strategy is chosen, an essential prerequisite for any gene identification project is the ability to construct
a high resolution genetic map around the locus of interest.
Affiliation(s): (2) Department of Medical Genetics, Wellcome Trust Centre for Molecular Mechanisms in Disease, University of Cambridge, Cambridge, UK
Book Title: Genomics Protocols
Series: Methods in Molecular Biology | Volume: 175 | Pub. Date: Jun-10-2001 | Page Range: 1-9 | DOI: 10.1385/1-59259-235-X:001
Subject: Genetics/Genomics
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