SpringerProtocols: Abstract: Fluorescent Detection of Telomerase Activity

Fluorescent Detection of Telomerase Activity

By: Wade K. Aldous², Amber J. Marean², Mary J. DeHart², Katherine H. Moore²

Abstract

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Telomerase is now a significant factor in the fight against cancer and antiaging (1). It is becoming a valuable prognostic tool to determine if a particular tissue is likely to develop cancer (2). The ability to detect telomerase activity in patients with cancer has also been correlated with clinical staging of some tumors (3-7). The regulation of telomerase and the ability to inhibit the enzyme is also an important aspect in future drug development for both anticancer and antiaging purposes (8-11). Thus, the most sensitive and accurate methods are needed to detect telomerase in various sample formats.

Affiliation(s): (2) Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, WA

Book Title: Telomeres and Telomerase: Methods and Protocols

Series: Methods in Molecular Biology | Volume: 191 | Pub. Date: Mar-01-2002 | Page Range: 137-146 | DOI: 10.1385/1-59259-189-2:137

Subject: Genetics/Genomics

References

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