SpringerProtocols: Abstract: Parkinson’s Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as α-Synucleinopathies

Parkinson’s Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as α-Synucleinopathies

By: Michel Goedert², Ross Jakes², R. Anthony Crowther², Maria Grazia Spillantini³

Abstract

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Parkinson’s disease (PD) is the most common neurodegenerative movement disorder (1). Neuropathologically, it is defined by nerve cell loss in the substantia nigra and the presence of Lewy bodies and Lewy neurites (2,3). In many cases, Lewy bodies are also found in the dorsal motor nucleus of the vagus, the nucleus basalis of Meynert, the locus coeruleus, the raphe nuclei, the midbrain Edinger-Westphal nucleus, the cerebral cortex, the olfactory bulb, and some autonomic ganglia (4).

Affiliation(s): (2) Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom
(3) Cambridge Centre for Brain Repair; Department of Neurology, University of Cambridge, Cambridge, United Kingdom

Book Title: Parkinsons Disease: Methods and Protocols

Series: Methods in Molecular Medicine | Volume: 62 | Pub. Date: Apr-20-2001 | Page Range: 33-59 | DOI: 10.1385/1-59259-142-6:33

Subject: Molecular Medicine

References

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