The use of biocatalysts in nonaqueous organic solvents is now a well-established method for the preparation of pharmaceutical products (1-2), food ingredients (3-5), and intermediates used in the fine chemicals industry (6-10). One of the advantages of this approach is that it enables the bioprocess operation at much higher concentrations of poorly water-soluble substrates, thus making both the synthesis and product recovery more attractive from a practical standpoint (11,12). However, many enzymes, and certainly microorganisms, still require a substantial amount of water present to maintain their catalytic activity at synthetically useful levels. In these cases, conventional aqueous-organic two-phase systems are still widely used, although the rates of mass transfer and inactivation of biocatalysts at the interface can be a serious drawback (13-16).