SpringerProtocols: Abstract: Poly(Lactide-Coglycolide) Microparticles As Vaccine Adjuvants

Poly(Lactide-Coglycolide) Microparticles As Vaccine Adjuvants

By: Derek T. O’ Hagan², Manmohan Singh²

Abstract

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Over the last 20 years, the adjuvant effect achieved through the association of antigens with polymeric microparticles has been repeatedly demonstrated (1,2). Encapsulation of antigens into microparticles, including submicron particles (nanoparticles), promotes their entry into lymph nodes and provides a high local concentration of antigen over an extended time-period. Microparticles also promote the interaction of encapsulated antigens with antigen presenting cells (APCs), e.g., macrophages.

Affiliation(s): (2) Chiron Corporation, Emeryville, CA

Book Title: Vaccine Adjuvants: Preparation Methods and Research Protocols

Series: Methods in Molecular Medicine | Volume: 42 | Pub. Date: Apr-15-2000 | Page Range: 91-103 | DOI: 10.1385/1-59259-083-7:91

Subject: Immunology

References

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