13. Electrochemotherapy of Murine Melanoma Using Intratumor Drug Administration
| Abstract |
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Administering a chemotherapeutic agent in combination with electric fields (electrochemotherapy; ECT) has been shown to be
an effective localized treatment for solid tumors (1). The drug used most often in this combination treatment has been bleomycin. ECT has been used successfully in both animal
studies and clinical trials (1–3). The treatment was initially performed by exposing tumor cells to electrical fields following intravenous injection of the
chemotherapeutic agent. Although ECT using intravenous bleomycin was successful, the procedure was limited by the existence
of a narrow but optimal time window for effective treatment as well as the fact that a systemic drug dose was being administered
for a localized therapy. In addition, the use of intravenous administration also precludes the treatment of patients with
poor circulation.
Affiliation(s): (3) Department of Surgery, College of Medicine, University of South Florida, Tampa, FL
(4) Department of Chemical Engineering, College of Engineering, University of South Florida, Tampa, FL
(4) Department of Chemical Engineering, College of Engineering, University of South Florida, Tampa, FL
Series: Methods in Molecular Medicine | Volume: 37 | Pub. Date: Feb-18-2000 | Page Range: 253-257 | DOI: 10.1385/1-59259-080-2:253
Subject: Cell Biology
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