SpringerProtocols: Abstract: 7. Clinical Trials for Solid Tumors Using Electrochemotherapy

7. Clinical Trials for Solid Tumors Using Electrochemotherapy

By: Richard Heller³, Richard Gilbert⁴, Mark J. Jaroszeski³

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Chemotherapy is a standard treatment for a wide variety of cancers. However, response rates are usually low. In melanoma, for example, partial response rates range from 20–45 % with complete responses of less than 5% (1–4). The cell membrane can be a significant barrier for agents with an intracellular site of action. The inability to cross the cell membrane and enter the cell could lead to a low response rate. The effectiveness of these agents could be enhanced if combined with a procedure that increases the permeability of the cell membrane.

Affiliation(s): (3) Department of Surgery, College of Medicine, University of South Florida, Tampa, FL
(4) Department of Chemical Engineering, College of Engineering, University of South Florida, Tampa, FL

Book Title: Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery: Electrically Mediated Delivery of Molecules to Cells

Series: Methods in Molecular Medicine | Volume: 37 | Pub. Date: Feb-18-2000 | Page Range: 137-156 | DOI: 10.1385/1-59259-080-2:137

Subject: Cell Biology

References

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