SpringerProtocols: Abstract: Clinical Protocol for p53 Gene Therapy for Liver Tumors

Clinical Protocol for p53 Gene Therapy for Liver Tumors

By: Michael D. Kelly², Ragai R. Mitry², Nagy A. Habib³

Abstract

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This chapter is intended to help other workers with the preparation of human gene therapy proposals. What follows is an abridged version of a protocol describing the use of gene replacement with p53 for liver tumors. This was submitted to the Gene Therapy Advisory Committee (GTAC) of the Department of Health (United Kingdom). This is the first trial to be approved by GTAC for gene therapy of liver tumors in humans.

Affiliation(s): (2) Liver Surgery Section, Imperial College School of Medicine, Hammersmith Hospital, London, UK
(3) Division of Surgery, Anaesthetics and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London, UK

Book Title: Hepatocellular Carcinoma: Methods and Protocols

Series: Methods in Molecular Medicine | Volume: 45 | Pub. Date: May-10-2000 | Page Range: 273-298 | DOI: 10.1385/1-59259-079-9:273

Subject: Cancer Research

References

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