SpringerProtocols: Abstract: 3. Tracing the Route Taken by Peptides and Major Histocompatibility Complex Class I Molecules in Presentation of Exogenous Antigens

3. Tracing the Route Taken by Peptides and Major Histocompatibility Complex Class I Molecules in Presentation of Exogenous Antigens

By: Christopher C. Norbury²

Abstract

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Since the discovery of cross priming by Bevan (1) nearly thirty years ago, a large amount of work has focused on defining the mechanisms that account for this in vivo phenomenon. Following the discovery that the majority of major histocompatibility complex (MHC-I)-bound peptides are derived from endogenous (intracellular) sources (2,3), a paradigm was established that exogenous (extracellular) antigens (Ags) are presented on MHC-I molecules and endogenous Ags are presented on MHC-II. In more recent years, accumulating evidence using a number of model systems, including presentation of bacterial (4,5), particulate (6) and soluble (7,8) Ag, has challenged that paradigm.

Affiliation(s): (2) Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

Book Title: Antigen Processing and Presentation Protocols

Series: Methods in Molecular Biology | Volume: 156 | Pub. Date: Sep-15-2000 | Page Range: 33-48 | DOI: 10.1385/1-59259-062-4:33

Subject: Immunology

References

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