SpringerProtocols: Abstract: Isolation and Detection of Microcystins and Nodularins, Cyanobacterial Peptide Hepatotoxins

Isolation and Detection of Microcystins and Nodularins, Cyanobacterial Peptide Hepatotoxins

By: Jussi Meriluoto², Linda Lawton³, Ken-ichi Harada⁴

Abstract

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Some species and strains within the freshwater cyanobacterial (blue-green algal) genera Microcystis, Oscillatoria (also known as Planktothrix), Anabaena, and Nostoc are known to produce cyclic heptapeptide liver toxins, microcystins. Closely related toxic cyclic pent ape ptides, nodularins, have been isolated from the brackish water cyanobacterium Nodularia spumigena. In addition, some cyanobacteria produce neurotoxic compounds such as anatoxin-a, anatoxin-a(s), and saxitoxins. Recent reviews of the chemical and biological properties of microcystins, nodularins, and other cyanobacterial toxins are given in refe. (1–4).

Affiliation(s): (2) Department of Biochemistry and Pharmacy, Åbo Akademi University, Turku, Finland
(3) School of Applied Sciences, Robert Gordon University, Aberdeen, UK
(4) Laboratory of Instrumental Analytical Chemistry Faculty of Pharmacy, Meijo University, Nagoya, Japan

Book Title: Bacterial Toxins: Methods and Protocols

Series: Methods in Molecular Biology | Volume: 145 | Pub. Date: Mar-10-2000 | Page Range: 65-87 | DOI: 10.1385/1-59259-052-7:65

Subject: Infectious Diseases

References

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