SpringerProtocols: Abstract: Both Irreversible Neuronal Death and Reversible Neuronal Stress Are Associated with Increased Levels of Statin, a Marker of Cell Cycle Arrest

Both Irreversible Neuronal Death and Reversible Neuronal Stress Are Associated with Increased Levels of Statin, a Marker of Cell Cycle Arrest

By: Patricia Boksa², Uwe Beffert², Doris Dea², Richard Alonso², Dayan O’Donnell², Judes Poirier²

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It is well known that cell death forms an important part of normal developmental and plastic processes in the brain. For example, during development, proliferating neuronal precursors generate a population of differentiated neurons, some of which make contact with their targets and survive. Neurons that cannot make appropriate targets activate an endogenous gene-directed death program (Cunningham, 1982; Oppenheimer, 1991). Thus, there is an important relationship between cell proliferation, differentiation, and death in neurons.

Affiliation(s): (2) Douglas Hospztal Research Centre, Centre for Studies on Aging, Departments of Psychiatry and Medzcine, McGill University, Montréal, Canada

Book Title: Apoptosis Techniques and Protocols

Series: Neuromethods | Volume: 29 | Pub. Date: Mar-01-1997 | Page Range: 161-182 | DOI: 10.1385/0-89603-451-8:161

Subject: Neuroscience

References

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