SpringerProtocols: Abstract: DNase I Footprinting

DNase I Footprinting

By: Keith R. Fox²

Abstract

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Footprinting provides a simple, quick, and reasonably inexpensive method for assessing the sequence specific interaction of ligands with DNA. Although the technique was developed in 1978 for studying the interaction of DNA-binding proteins with then target sites (1), it has proved invaluable for determining the sequence specificity of many small ligands

Affiliation(s): (2) Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, UK

Book Title: Drug-DNA Interaction Protocols

Series: Methods in Molecular Biology | Volume: 90 | Pub. Date: Oct-07-1997 | Page Range: 1-22 | DOI: 10.1385/0-89603-447-X:1

Subject: Genetics/Genomics

References

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