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Diffusion and Ion Shifts in the Brain Extracellular Microenvironment and Their Relevance for Voltammetric Measurements: The Brain Is Not a Beaker: In Vivo vs In Vitro Voltammetry
Abstract
The space between cells of the brain is not just a void separating membranes, but a complex milieu that plays an essential role in many brain functions. The term brain extracellular microenvironment (BEM) will be used here to designate the environment encountered by a molecule when that molecule is in the space between cells of the brain. A similar term (brain cell microenvironment) was coined by Schmitt and Samson (1969). As our ideas have matured, it has become necessary to distinguish the extracellular from the intracellular microenvironment so the term BEM is now more appropriate. Several publications have refined and developed the concepts that are now embodied in the BEM; see especially Nicholson (1979,1980), Schmitt (1984), Cserr (1986), and Fuxe and Agnati (1991).
Affiliation(s): (4) Departments of Neurosurgery, Physiology, and Biophysics, New York University Medical Center, New York, NY
Series: Neuromethods  |  Volume: 27  |  Pub. Date: Apr-27-1995  |  Page Range: 27-79  |  DOI: 10.1385/0-89603-312-0:27
Subject:  Neuroscience
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