SpringerProtocols: Abstract: Antisense-Mediated Inhibition of Protein Synthesis: Rational Drug Design, Pharmacokinetics, Intracerebral Application, and Organ Uptake of Phosphorothioate Oligodeoxynucleotides

Antisense-Mediated Inhibition of Protein Synthesis: Rational Drug Design, Pharmacokinetics, Intracerebral Application, and Organ Uptake of Phosphorothioate Oligodeoxynucleotides

By: Wolfgang Brysch², Abdalla Rifai², Wolfgang Tischmeyer², Karl-Hermann Schlingensiepen²

Abstract

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There is hardly any class of drugs for which the term “ratronal drug design” is more appropriate than for the currently developing antisense therapeutics. The specrficlty of the hybridization reaction and the surprisingly efficient uptake of synthetrc oligonucleotide derivatives provide a new class of selective protein synthesis inhibitors. Concurrently with the development of the antisense technology, elucidation of the pathogenetic role of mdrvrdual proteins for certain diseases is rapidly progressing, most notably in the fields of cancer research and virology. Consequently, the first clinical trtals are being conducted with antrsense therapeutics for the treatment of viral diseases and neoplasms.

Affiliation(s): (2) Max-Planck Institute for Biophysical Chemistry, Gottingen, Germany

Book Title: Antisense Therapeutics

Series: Methods in Molecular Medicine | Volume: 1 | Pub. Date: Mar-25-1996 | Page Range: 159-182 | DOI: 10.1385/0-89603-305-8:159

Subject: Cell Biology

References

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