SpringerProtocols: Abstract: Antisense Therapy of Hepatitis B Virus Infection: In Vivo Analyses in the Duck Hepatitis B Virus Model

Antisense Therapy of Hepatitis B Virus Infection: In Vivo Analyses in the Duck Hepatitis B Virus Model

By: Wolf-Bernhard Offensperger², Silke Offensperger², Hubert E. Blum³

Abstract

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Infectious diseases in general and viral infections in particular can be viewed as acquired genetic diseases (1, 2). At the molecular level, clinical signs and symptoms of viral infections are frequently caused by the expression or overexpression of the acquired genes. Based on this basic concept, such acquired genetic diseases should be amenable to treatment by a specific block of gene expression. Gene expression can be blocked at different levels by the following strategtes: sense strategy, antigene strategy, ribozymes, antisense strategy, and interfering peptrdes or proteins (Fig. 1).

Affiliation(s): (2) Department of Medicine, University of Freiburg, Germany
(3) Department of Medicine, University Hospital, Zurich, Switzerland

Book Title: Antisense Therapeutics

Series: Methods in Molecular Medicine | Volume: 1 | Pub. Date: Mar-25-1996 | Page Range: 143-158 | DOI: 10.1385/0-89603-305-8:143

Subject: Cell Biology

References

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1.	Anderson, W F. (1992) Human gene therapy. Science 256, 808–813

2.	Morgan, R A and Anderson, W F (1993) Human gene therapy. Annu Rev Biochem. 62, 191–217

3.	Agrawal, S (1992) Antisense oligonucleotides as antiviral agents. Trends Biotechnol 10, 281–287

4.	Helene, C (1991) Rational design of sequence-specific oncogene inhibitors based on antisense and antigene oligonucleotides. Eur J. Cancer 27, 1466–1471

5.	Helene, C and Toulme, J. J (1990) Specific regulation of gene expression by antisense, sense and antigene nucleic acids. Biochem Biophys Acta 1049, 99–125

6.	Uhlmann, E and Peyman, A. (1990) Antisense oligonucleotides: a new therapeutic principle. Chem Rev 90, 544–583

7.	Wickstrom, E (1992) Strategies for administering targeted therapeutic oligo-deoxynucleotides A review. Trends Biotechnol 10, 281–287.

8.	Calabretta, B. (1991) Inhibition of protooncogene expression by antisense ohgodeoxynucleotides: biological and therapeutic imphcations. Cancer Res 51, 4505–4510.

9.	Ma, D. D. F. and le Doan, T (1994) Antisense oligonucleotide therapies: are they the “magic bullets”? Ann Intern Med 120, 161–163.

10.	Stem, C A. and Cohen, J S. (1988) Oligodeoxynucleotides as inhibitors of gene expression. a review. Cancer Res 48, 2659–2668

11.	Becker, D., Meler, C B. and Herlyn, M (1989) Proliferation of human malignant melanomas is inhibited by antisense ohgodeoxynucleotides targeted against basic fibroblast growth factor EMBO J 8, 3685–3691

12.	Harel-Bellan, A., Ferris, D. K., Vinocour, M., Holt, J. T., and Farrar, W. L. (1988) Specific inhibition of c-myc protein biosynthesis using an antisense synthetic deoxyoligonucleotide in human T lymphocytes. J Immunol 140, 243l–2435

13.	Holt, J. T., Redner, R L., and Ntenhms, A. W. (1988) An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation. Mel Cell Biol 8, 963–973

14.	McManaway, M E., Neckers, L. M., Loke, S. L., Al-Nasser, A A., Redner, R L., Shiramizu, B T., Goldschmidts, W L., Huber, B E., Bhatia, K., and Magrath, I T (1990) Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide. Lancet 335, 808–811

15.	Melam, C., Rivoltini, L., Parmiani, G., Calabretta, B., and Colombo, M P (1991) Inhibition of proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcmoma cell lines that express c-myb Cancer Res 51, 2897–2901

16.	Reed, J C., Stem, C, Subasinghe, C, Haldar, S., Croce, C M., Yum, S., and Cohen, J. (1990) Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate ohgodeoxynucleotides Cancer Res 50, 6565–6570

17.	Rivera, R T., Pasion, S. G., Wong, D T., Fet, Y B., and Biswas, D K. (1989) Loss of tumorigenic potential by human lung tumor cells in the presence of antisense RNA specific to the ectopically synthesized alpha subunit of human chorionic gonadotropin J Cell Biol 108, 2423–2434.

18.	Saison-Behmoaras, T., Tocque, B., Rey, I., Chassignol, M., Thuong, N T., and Helene, C. (1991) Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation EMBOJ 10, 1111–1118.

19.	Szczylik, C., Skorskt, T., Nicolaides, N. C., Manzella, L., Malaguarnera, L., Venturelli, D., Gewntz, A. M., and Calabretta, B. (1991) Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides Science 253, 562–565.

20.	von Ruden, T and Gilboa, E (1989) Inhibition of human T-cell leukemia virus type I replication in primary human T cells that express antisense RNA J. Virol 63, 677–682

21.	Kabanov, A V., Vinogradov, S. V., Ovcharenko, A. V., Krivonos, A V., Melik, N. N. S., Kiselev, V I., and Severm, E. S. (1990) A new class of antivirals. antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus reproduction and synthesis of virus-specific proteins in MDCK cells FEBS Lett 259, 327–330.

22.	Chang, L J. and Stoltzfus, C M. (1987) Inhibition of Rous sarcoma virus replication by antisense RNA J Virol 61, 92l–924.

23.	Zamecnik, P. C. and Stephenson, M. L. (1978) Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide Proc Natl Acad Sci USA 75, 280–284

24.	Agrawal, S., Goodchild, J, Civeira, M P., Thornton, A H., Sarin, P. S., and Zamecnik, P C (1988) Oligodeoxynucleoside phosphoramidates and phos-phorothioates as inihibitors of human immunodeficiency virus Proc Natl Acad Sci USA 85, 7079–7083

25.	Matsukura, M., Shinozuka, K., Zon, G., Mitsuya, H., Reitz, M., Cohen, J S., and Broder, S (1987) Phosphorothioate analogs of oligodeoxynucleotides inhibitors of replication and cytopathic effects of human immunodeficlency virus. Proc Natl Acad Sci USA 84, 7706–7710

26.	Renneisen, K., Leserman, L., Matthes, E., Schroder, H C., and Muller, W E (1990) Inhibition of expression of human immunodeficiency virus-l in vitro by antibody-targeted hposomes contaming antisense RNA to the env region. J Biol Chem 265, 16,337–l6,342.

27.	Zamecmk, P C., Goodchild, J., Taguchi, Y., and Sarin, P S (1986) Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA Proc Natl Acad Sci USA 83, 4143–4146

28.	Lemaitre, M., Bayard, B., and Lebleu, B (1987) Specific antiviral activity of a poly-lysine-conjugated ohgodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site Proc Natl Acad Sci USA 84, 648–652

29.	Smith, C C., Aurelian, L., Reddy, M P., Miller, P S., and Ts’o, P O P (1986) Antiviral effect of an oligo (nucleoside methylphosphonate) complementary to the splice Junction of herpes simplex virus type 1 immediate early pre-mRN As 4 and 5 Proc Natl Acad Sci USA 83, 2787–2791.

30.	Bergman, P., Ustav, M, Moreno-Lopez, J., Vennstroem, B., and Pettersson, U (1986) Rephcation of the bovme papillomavirus type 1 genome, antisense transcripts prevent episomal replication Gene 50, 185–193

31.	Gupta, K. C (1987) Antisense oligodeoxynucleotides provide insight into mechanism of translation initiation of two Sendai virus mRNAs. J Biol Chem 262, 7492–7496

32.	Blum, H. E., Galun, E., von Weizsacker, F., and Wands, J R. (1991) Inhibition of hepatitis B virus by antisense oligodeoxynucleotides (letter). Lancet 337, 1230

33.	Goodarzi, G., Gross, S C., Tewari, A., and Watabe, K. (1990) Antisense oligodeoxyribonucleotides inhibit the expression of the gene for hepatitis B virus surface antigen J Gen Virol 71, 3021–3025

34.	Wu, G. Y. and Wu, C. H (1992) Specific inihibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides. J Biol Chem 267, 12,436–12,439

35.	Wands, J R and Blum, H E (1991) Primary hepatocellular carcmoma N Engl J Med 325, 729–731

36.	Tiollais, P., Pourcel, C., and DeJean, A (1985) The hepatitis B virus Nature 317, 489–495

37.	Summers, J., Smolec, J. M., and Snyder, R (1978) A virus similar to hepatitis B virus associated with hepatitis and hepatoma in woodchucks Proc Natl Acad Sci USA 75, 4533–4537

38.	Marion, P L, Oshiro, L S., Regnery, DC., Scullard, G H., and Robinson, W S (1980) A virus in Beechey ground squirrels that is related to hepatitis B virus of humans Proc Natl Acad Sci USA 77, 2941–2945

39.	Mason, W S., Seal, G., and Summers, J (1980) Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus J Virol 36, 829–836

40.	Sprengel, R., Kaleta, E F., and Will, H (1988) Isolation and characterization of a hepatitis B virus endemic in herons. J Virol 62, 3832–3839.

41.	Summers, J W and Mason, W S. (1982) Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA mtermediate Cell 29, 403–415

42.	Carman, W., Thomas, H., and Domingo, E. (1993) Viral genetic variation: hepatitis B virus as a climcal example Lance, 341, 349–353

43.	Tuttleman, J. S., Pugh, J C and Summers, J W. (1986) In vitro experimental mfection of primary duck hepatocyte cultures with duck hepatitis B virus J Virol. 58, 17–25.

44.	Suzuki, S., Lee, B., Luo, W., Tovell, D., Robins, M J., and Tyrrell, D. L. (1988) Inhibition of duck hepatitis B virus replication by purme 2′, 3′-dideoxynucleosides Biochem. Biophys Res Commun 156, 1144–1151

45.	Fourel, I, Gripon, P., Hantz, O., Cova, L., Lambert, V., Jacquet, C., Watanabe, K., Fox, J., Guillouzo, C., and Trepo, C. (1989) Prolonged duck hepatitis B virus replication in duck hepatocytes cocultivated with rat epithelial cells. a useful system for antiviral testing Hepatology 10, 186–191

46.	Civitico, G., Wang, Y Y., Luscombe, C., Bishop, N., TachedJian, G., Gust, I, and Locarnini, S (1990) Antiviral strategies in chronic hepatitis B virus infection II Inhibition of duck hepatitis B virus in vitro using conventional antiviral agents and supercoiled-DNA active compounds. J Mede Virol 31, 90–97

47.	Hirota, K., Sherker, A H., Omata, M., Yokosuka, O., and Okuda, K (1987) Effects of adenme arabmosrde on serum and intrahepatic replicative forms of duck hepatitis B virus in chronic infection Hepatology 7, 24–28.

48.	Kassianides, C., Hoofnagle, J H., Miller, R. H., Doe, E., Ford, H., Broder, S., and Mitsuya, H (1989) Inhibition of duck hepatitis B virus replication by 2’,3’-dideoxycytidine A potent inhibitor of reverse transcriptase. Gastroenterology 97, 1275–1280.

49.	Sherker, A. H., Hirota, K., Omata, M., and Okuda, K. (1986) Foscarnet decreases serum and liver duck hepatitis B virus DNA in chronically infected ducks. Gustroenterology 91, 818–824

50.	Iyer, R P., Philips, L. R., Egan, W., Regan, J. B., and Beaucage, S L J (1990) The automated synthesis of sulphur-containing ohgodeoxyribonucleotides using 3H-1,2-benzodithiol-3-one 1,l-dioxide as a sulphur-transfer reagent Org Chem 55, 4693–4698

51.	Leonetti, J. P., Mechti, N., Degols, G., Gagnor, C., and Lebleu, B (1991) Intra-cellular distribution of microinJected antisense oligonucleotides Proc Nutl Acad. Sci USA 88, 2702–2706

52.	Stein, C. A. and Cheng, Y C. (1993) Antisense oligonucleotides as therapeutic agents-is the bullet really magical? Science 261, 1004–1012

53.	Hanvey, J. C., Peffer, N J., Bisi, J. E., Thomson, S. A., Cadilla, R., Josey, J. A., Ricca, D. J., Hassman, C. F., Bonham, M. A., Au, K. G., et al (1992) Antisense and antigene properties of peptide nucleic acids. Science 258, 1481–1485

54.	Wagner, R W., Matteucct, M. D., Lewis, J G., Gutterrez, A J., Moulds, C., and Froehler, B C (1993) Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines. Science 260, 1510–1513.

55.	Duval-Valentin, G., Thuong, N. T., and Helene, C. (1992) Specitic inhibition of transcription by triple helix-forming oligonucleotides. Proc Natl Acad Sci USA 89, 504–508

56.	Felgner, P L., Gadek, T R., Holm, M., Roman, R, Chart, H W., Wenz, M., Northrop, J P., Ringold, G. M., and Damelsen, M (1987) Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 84, 7413–7417

57.	Leonetti, J P., Machy, P., Degols, G., Lebleu, B., and Leserman, L (1990) Antibody-targeted hposomes containing oligodeoxyribonucleotides complementary to viral RNA selectively inhibit viral replication. Proc Natl Acad Sci USA 87, 2448–2451

58.	Liang, T J., Makdisi, W. J., Sun, S., Hasegawa, K., Zhang, Y., Wands, J R., Wu, C H., and Wu, G. Y. (1993) Targeted transfection and expression of hepatitis B viral DNA in human hepatoma cells. J Clin Invest 91, 1241–1246

59.	Cotten, M., Wagner, E., Zatloukal, K., Phillips, S., Curiel, D. T., and Birnstiel, M L (1992) High-efficiency receptor-mediated delivery of small and large (48 kilobase) gene constructs using the endosome-disruption activity of defective or chemically mactivated adenovirus particles. Proc Natl Acad Sci USA 89, 6094–6098

60.	Cristiano, R J., Smith, L C., and Woo, S. L. (1993) Hepatic gene therapy: adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes. Proc. Natl Acad Sci USA 90, 2122–2126

61.	Wagner, E., Zenke, M., Cotten, M., Beug, H., and Birnstiel, M. L. (1990) Trans-ferrm-polycation coqugates as carriers for DNA uptake into cells. Proc Natl Acad Sci USA 87, 3410–3414

62.	Kay, M A., Baley, P., Rothenberg, S., Leland, F., Fleming, L., Ponder, K. P., Liu, T., Finegold, M., Darlington, G., Pokorny, W., and Woo, S. L C (1992) Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes. Proc Natl. Acad. SCi USA 89, 89–93.

63.	Ledley, F D., Darlington, G. J., Hahn, T., and Woo, S L. (1987) Retroviral gene transfer into primary hepatocytes imphcations for genetic therapy of liver-spe-cific functions. Proc. Natl Acad. Sci USA 84, 5335–5339.

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