SpringerProtocols: Abstract: c-Myb in Smooth Muscle Cells

c-Myb in Smooth Muscle Cells

By: Michael Simons², Robert D. Rosenberg²

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The proto-oncogene c-myb is a cellular homolog of a viral oncogene v-myb found in two independently derived avian acute leukemia viruses: avian myeloblastosis vn-us (AMV) and E26 leukemia virus (1). The myb gene is highly conserved in eukaryotes, and it usually consists of 15 exons spanning over 35 kb of genomic DNA (1).In humans, c-myb gene locus has been mapped to chromosome 6 (6q22-23) However, myb mRNA expressed in thymus contains transcripts originating from chromosome 17 (17q25), suggesting that an mtermolecular recombinant event may be involved in the formation of the mature protein (2).

Affiliation(s): (2) Department of Biology, Massachusetis Institute of Technology, Cambridge, MA

Book Title: Antisense Therapeutics

Series: Methods in Molecular Medicine | Volume: 1 | Pub. Date: Mar-25-1996 | Page Range: 121-141 | DOI: 10.1385/0-89603-305-8:121

Subject: Cell Biology

References

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