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8. Detection of Mutations by the Amplification Refractory Mutation System (ARMS)
The amplification refractory mutation system (ARMS) is a simple and rapid method of detecting point mutations, restriction fragment length polymorphisms (RFLPs), and small nucleotide insertions or deletions. The method was first described by Newton et al. (1) for analyzing single DNA base differences in patients with α-1-antitrypsin deficiency and has since been applied to prenatal diagnosis and carrier detection of cystic fibrosis (2) and β-thalassemia (3).
Affiliation(s): (1) National Haemoglobinopathy Reference Laboratory, Institute of Moleculst Medicine, John Radcliffe Hospital, Oxford, UK
Series: Methods in Molecular Biology  |  Volume: 9  |  Pub. Date: Nov-01-1991  |  Page Range: 77-84  |  DOI: 10.1385/0-89603-205-1:77
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