SpringerProtocols: Abstract: Haplotype Association Mapping in Mice

12. Haplotype Association Mapping in Mice

By: Shirng-Wern Tsaih¹, Ron Korstanje¹

Abstract

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Haplotype Association Mapping (HAM) is a novel phenotype-driven approach to identify genetic loci and was originally developed for mice. This method, which is similar to Genome-Wide Association (GWA) studies in humans, looks for associations between the phenotype and the haplotypes of mouse inbred strains, treating inbred strains as individuals. Although this approach is still in development, we review the current literature, present the different methods and applications that are in use, and provide a glimpse of what is to come in the near future.

Affiliation(s): (1) The Jackson Laboratory, Bar Harbor, ME, USA

Book Title: Cardiovascular Genomics: Methods and Protocols

Series: Methods in Molecular Biology | Volume: 573 | Pub. Date: Sep-15-2009 | Page Range: 213-222 | DOI: 10.1007/978-1-60761-247-6_12

Subject: Genetics/Genomics

Key Words: Haplotypes - association - mice

References

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