SpringerProtocols: Abstract: 7. Label-Free Detection with the Liquid Core Optical Ring Resonator Sensing Platform

7. Label-Free Detection with the Liquid Core Optical Ring Resonator Sensing Platform

By: Ian M. White⁵, Hongying Zhu⁵, Jonathan D. Suter⁵, Xudong Fan⁵, Mohammed Zourob⁶

Abstract

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Optical label-free detection prevents the cost and complexity of fluorescence and radio labeling while providing accurate quantitative and kinetic results. We have developed a new optical label-free sensor called the liquid core optical ring resonator (LCORR). The LCORR integrates optical ring resonator sensors into the microfluidic delivery system by using glass capillaries with a thin wall. The LCORR is capable of performing refractive index detection on liquid samples, as well as bio/chemical analyte detection down to detection limits on the scale of pg/mm² on a sensing surface.

Affiliation(s): (5) Biological Engineering Department, University of Missouri-Columbia, Columbia, MO, USA
(6) Biosensors Division, Biophage Pharma, Montreal, QC, Canada

Book Title: Biosensors and Biodetection

Series: Methods in Molecular Biology | Volume: 503 | Pub. Date: Nov-11-2008 | Page Range: 139-165 | DOI: 10.1007/978-1-60327-567-5_7

Subject: Imaging/Radiology

Key Words: Optical ring resonator - LCORR - Whispering gallery modes - Refractive index detection - Protease detection - DNA sequence detection

References

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