SpringerProtocols: Abstract: Whole-Genome Microarrays: Applications and Technical Issues

3. Whole-Genome Microarrays: Applications and Technical Issues

By: Brian D. Gregory¹, Dmitry A. Belostotsky²

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DNA microarrays have become a mainstream tool in experimental plant biology. The constant improvements in the technological platforms have enabled the development of the tiling DNA microarrays that cover the whole genome, which in turn catalyzed the wide variety of creative applications of such microarrays in the areas as diverse as global studies of genetic variation, DNA-binding proteins, DNA methylation, and chromatin and transcriptome dynamics. This chapter attempts to summarize such applications as well as discusses some technical and strategic issues that are particular to the use of tiling microarrays.

Affiliation(s): (1) Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA
(2) School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO, USA

Book Title: Plant Systems Biology

Series: Methods in Molecular Biology | Volume: 553 | Pub. Date: Jan-01-2009 | Page Range: 39-56 | DOI: 10.1007/978-1-60327-563-7_3

Subject: Plant Sciences

Key Words: Tiling arrays - transcriptome - tilemap - Arabidopsis - rice

References

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