SpringerProtocols: Abstract: 2. Percent Labeled Mitosis Curve Analysis

2. Percent Labeled Mitosis Curve Analysis

By: Stanley E. Shackney¹, Paul S. Ritch²

Abstract

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The measurement of percent labeled mitoses (PLM, or alternatively, FLM, for fraction of labeled mitoses) was developed in 1959 by Quastler and Sherman (8) for estimating the durations of the component phases of the cell cycle.

Affiliation(s): (1) Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland
(2) Department of Medicine, The Medical College of Wisconsin, Milwaukee, Wisconsin

Book Title: Techniques in Cell Cycle Analysis

Series: No Series | Pub. Date: Feb-04-1987 | Page Range: 31-45 | DOI: 10.1007/978-1-60327-406-7_2

Subject: Cell Biology

References

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3.	Lala, P. K. and Patt, H. M. Cytokinetic analysis of tumor growth. Proc. Nat. Acad. Sci. USA, 56: 1735–1742, 1966.

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7.	Quastler, H. The analysis of cell population kinetics. In: (L. F. Lamerton and R. J. M. Fry, eds.), Cell Proliferation, Blackwell Scientific, Oxford, 1963.

8.	Quastler, H. and Sherman, F. G. Cell population kinetics in the intestinal epithelium of the mouse. Exp. Cell Res., 17: 420–438, 1959.

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12.	Simpson-Herren, L. Autoradiographic techniques for measurement of the labeling index. In: (J. W. Gray and Z. Darzynkiewicz, eds.), Techniques in Cell Cycle Analysis, Humana, New Jersey, 1986.

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14.	Steel, G. G. and Hanes, S. The technique of labeled mitoses: Analysis by automatic curve-fitting. Cell Tissue Kinet., 4: 93–105, 1971.

15.	Takahashi, M., Hogg, G. D., and Mendelsohn, M. L. The automatic analysis of FLM curves. Cell Tissue Kinet., 4: 505–518, 1971.

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