Springer Protocols: Abstract: 15. Bilirubin and Its Carbohydrate Conjugates

15. Bilirubin and Its Carbohydrate Conjugates

By: Norbert J. C. Blanckaert^{2 3}

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In mammals, the open tetrapyrrole bilirubin (structure 2, Fig. 1) is the principal degradation product of iron-protoporphyrin-IX (heme). The latter molecule is a tetrapyrrolic macrocycle and plays a critical role in aerobic metabolism by reversibly binding oxygen in hemoglobin and myoglobin, and by serving as the active site in oxidation reactions catalyzed by hemoprotein enzymes. Important cyclic tetrapyrroles in nature related to heme are chlorophylls, which contain magnesium and are derived from protoporphyrin-IX, and vitamin B₁₂, a corrinoid derived from uroporphyrinogen-III.

Affiliation(s): (2) Department of Laboratory Medicine and Liver Center, University of California Medical Center, San Francisco, California
(3) Department of Medical Research, Campus Gasthuisberg, University of Leuven, Leuven, Belgium

Book Title: Liquid Chromatography In Clinical Analysis

Series: Methods in Molecular Biology | Pub. Date: Apr-30-1981 | Page Range: 355-379 | DOI: 10.1007/978-1-60327-404-3_15

Subject: Biochemistry

References

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1.	Berk, P. D., and Javitt, N. B., Am. J. Med 64, 311 (1978).

2.	Billing, B. H., Gut 19, 481 (1978).

3.	Fevery, J. Blanckaert, N., Degroote, J., and Heirwegh, K. P. M., Bilirubin conjugates: formation and detection, in Progress in Liver Disease, Popper, H., and Schaffner, F., eds., vol. 5, Grune and Stratton, New York, 1976, pp. 183–214.

4.	Schmid, R., Gastroenterology 74, 1307 (1978).

5.	Schmid, R., and McDonagh, A. F., Hyperbilirubinemia, in The Metabolic Basis of Inherited Disease, Stanbury, J. B., Wyngaarden, J. B., and Frederickson, D. S., eds., McGraw-Hill, New York, 1978, pp. 1221–1257.

6.	Bonnett, R., Nomenclature, in The Porphyrins, Dolphin, D., ed., vol. 1, Academic Press, New York, 1978, pp. 1–27.

7.	Heirwegh, K. P. M., Fevery, J., Meuwissen, J. A. T. P., Degroote, J., Compernolle, F., Desmet, V., and Van Roy, F. P., Methods Biochem. Anal 11, 205 (1974).

8.	Brodersen, R., and Theilgaard, J., Scand J. Clin. Lab. Med. 24, 395 (1969).

9.	Fog, J., and Jellum, E., Nature 198, 88 (1963).

10.	Bonnett, R., Davies, J. E., Hursthouse, M. B., and Sheldrick, G. M., Proc. Roy. Soc. Lond B. 202, 249 (1978).

11.	Mugnoli, A., Manitto, P., and Monti, D., Nature 273, 568 (1978).

12.	Lester, R., and Klein, P., J. Clin. Invest. 45, 1839 (1966).

13.	Blanckaert, N., Heirwegh, K. P. M., and Zaman, Z., Biochem. J. 164, 229 (1977).

14.	Jones, E. A., Shrager, R., Bloomer, J. R., Berk, P. D., Howe, R. B., and Berlin, N. I., J. Clin. Invest. 51, 2450 (1972).

15.	Heirweigh, K. P. M., Formation, metabolism and significance of bilirubin-IX glycosides, in Conjugation Reactions in Drug Biotransformation, Aitio, A., ed., Elsevier/North, Holland Biomedical Press, Amsterdam, 1978, pp. 67–76.

16.	Blanckaert, N., Compernolle, F., Leroy, P., Van Houtte, R., Fevery, J., and Heirwegh, K. P. M., Biochem. J., 171, 203 (1978).

17.	Compernolle, F., Van Hees, G. P., Blanckaert, N., and Heirwegh, K. P. M., Biochem. J. 171, 185 (1978).

18.	Kuenzle, C. C, Bilirubin conjugates in human bile, in Metabolic Conjugation and Metabolic Hydrolysis, Fishman, W. H., ed., vol. 3, Academic Press, New York, 1973, pp. 351–386.

19.	Compernolle, F., Biochem. J. 175, 1095 (1978).

20.	Isselbacher, K. J., and McCarthy, E. A., J. Clin. Invest. 38, 645 (1959).

21.	Noir, B., and Nanet, H., Biochim. Biophys. Acta. 372, 230 (1974).

22.	Kondo, T., Kawai, T., Yamamoto, T., and Izawa, T., Gastroenterol. Jap. 6, 217 (1971).

23.	Ettner-Kjelsaas, H., and Kuenzle, C. C., Biochim. Biophys. Acta. 400, 83 (1975).

24.	Weber, A. P., and Schalm, L., Acta. Med. Scand 177, 519 (1965).

25.	Jansen, P. L. M., Chowdhury, J. R., Fischberg, E. B., and Arias, I. M., J. Biol. Chem. 252, 2710 (1977).

26.	Blanckaert, N., Gollan, J., and Schmid, R., Proc. Natl. Acad. Sci., USA 76, 2037 (1979).

27.	Gordon, E. R., and Goresky, C. A., Gastroenterol. 75, 966 (1978).

28.	Blanckaert, N., Gollan, J., and Schmid, R., J. Clin. Invest. 65, 1332 (1980).

29.	Watson, C. J., Ann. Intern. Med. 70, 839 (1969).

30.	Bloomer, J. R., Berk, P. D., Howe, W. B., Waggoner, J. G., and Berlin, N. I., Clin. Chim. Acta. 29, 463 (1970).

31.	Billing, B. H., Cole, P. G., and Lathe, G. H., Biochem. J. 65, 774 (1957).

32.	Schmid, R., J. Biol. Chem. 11, 881 (1957).

33.	Talafant, E., Nature (London) 178, 312 (1956).

34.	Blanckaert, N., Kabra, P. M., Farina, F. A., Stafford, B. E., Marton, L. J., and Schmid, R., J. Lab. Clin. Med. 96, 198 (1980).

35.	Ehrlich, P., Centr. klin. Med. 4, 721 (1883).

36.	Van den Bergh, A. A. H., and Muller, P., Biochem. Z., 77, 90 (1916).

37.	Billing, B. H., Haslam, R., and Wald, N., Ann. Clin. Biochem., 8, 21 (1971).

38.	Van Roy, F. P., and Heirwegh, K. P. M., Biochem. J. 107, 507 (1968).

39.	Hertz, H., Dybkaer, R., and Lauritzen, M., Scand. J. Clin. Lab. Invest. 34, 265 (1974).

40.	Jackson, S. H., and Hernandez, A. H., Clin. Chem. 16, 462 (1970).

41.	Liley, A., Amer. J. Obstet. Gynecol. 82, 1359 (1961).

42.	Ostrow, J. D., and Murphy, N. H., Biochem. J. 120, 311 (1970).

43.	Brodersen, R., and Jacobsen, J., Separation and determination of bile pigments, in Methods of Biochemical Analysis, Glick, D., ed., Vol. 17, Wiley-Interscience, New York, 1969, pp. 3–54.

44.	Weber, A. P., and Schalm, L., Clin. Chim. Acta. 7, 805 (1962).

45.	Eberlein, W. R., Pediatrics 25, 878 (1960).

46.	Ostrow, J. D., and Boonyapisit, S. T., Biochem. J. 173, 263 (1978).

47.	Bratlid, D., and Winsnes, A., Scand. J. Clin. Lab. Invest. 28, 41 (1971).

48.	Schoenfield, L. J., Foulk, W. T., and Bollman, J. L., Gastroenterology 47, 35 (1964).

49.	Cole, P. G., Lathe, G. H., and Billing, B. H., Biochem. 57, 514 (1954).

50.	Kuenzle, C. C., Maier, C., and Ruttner, J. R., J. Lab. Clin. Med. 67, 294 (1966).

51.	Wolkoff, A. W., Scharschmidt, B. F., Plotz, P. H., and Berk, P. D., Proc. Soc. Exptl. Biol. Med 152, 20 (1976).

52.	Billing, B. H., J. Clin. Path. 8, 130 (1955).

53.	Gordon, E. R., Chan, T. H., Samodai, K., and Goresky, C. A., Biochem. J. 167, 1 (1977).

54.	Thompson, R. P. H., and Hofmann, A. F. Clin. Chim. Acta. 35, 517 (1971).

55.	Salmon, M., Fenselau, C, Life Sci. 15, 2069 (1974).

56.	Heirwegh, K. P. M., Fevery, J., Michiels, R., Van Hees, G. P., and Compernolle, F., Biochem. J. 145, 185 (1975).

57.	Noir, B. A., Biochem. J. 155, 365 (1976).

58.	Blumenthal, S. G., Taggart, D. B., Ikeda, R. M., Ruebner, B. H., and Bergstrom, D. E., Biochem. J. 167, 535 (1977).

59.	Jansen, F. H., and Billing, B. H., Biochem. J. 125, 917 (1971).

60.	Lim, C. K., J. Liq. Chromatog. 2, 37 (1979).

61.	Onishi, S., Itoh, S., Kawade, N., Isobe, K., and Sugiyama, S., Biochem. J. 185, 281 (1980).

62.	Yamaguchi, T., Yamaguchi, N., Nakajima, H., Komoda, Y., and Ishikawa, M., Proc. Japan Acad. 55, Ser. B., 89 (1979).

63.	Blanckaert, N., Biochem. J. 185, 115 (1980).

64.	Scharschmidt, B. F., Blanckaert, N., Farina, F., Kabra, P., Weisiger, R., Marton, L., and Schmid, R., Gastroenterology 77, A–39 (1979).

65.	Rosenthal, P., Blanckaert, N., Kabra, P. M., and Thaler, M. M., Gastroenterology 77, A–35 (1979).

66.	Bratlid, D., and Winsnes, A., Scand. J. Clin. Lab. Invest. 31, 231 (1973).

67.	Blanckaert, N., Fevery, J., Heirwegh, K. P. M., and Compernolle, F., Biochem. J. 164, 237 (1977).

68.	Blumenthal, S. G., Stucker, T., Rasmusssen, R. D., Ikeda, R. M., Ruebner, B. H., Bergstrom, D. E., and Hanson, F. W., Biochem. J. 186, 693 (1980).

69.	Blanckaert, N., Heirwegh, K. P. M., and Compernolle, Biochem. J. 155, 405 (1976).

70.	Yamaguchi, T., Yamaguchi, N., Nakajima, H., Komoda, Y., and Ishikawa, M., Proc. Japan Acad. 55, Ser. B., 84 (1979).

71.	McDonagh, A. F., and Assisi, F.: FEBS Lett. 18, 315 (1971).

72.	Wooldridge, T. A., and Lightner, D. A., J. Liq. Chromatog. 1, 653 (1978).

73.	Lightner, D. A., Wooldridge, T. A., and McDonagh, A. F., Proc. Natl. Acad. Sci. USA 76, 29 (1979).

74.	Onishi, S., Itoh, S., Kawade, N., Isobe, K., and Sugiyama, S., Biochem. Biophys. Res. Comm. 90, 890 (1979).

75.	Brodersen, R., Detection of free bilirubin: a criterion for exchange transfusion, in Liver Diseases in Infancy and Childhood, Berenberg, S. R., ed., Martinus Nijhoff, The Hague, 1976, pp. 18–24.

76.	Lu, K. C., Gooding, K. M., and Regnier, F. E., Clin. Chem. 25, 1608 (1979).

77.	Schoch, S., Lempert, U., Wieschoff, H., and Scheer, H., J. Chromatog. 157, 357 (1978).

78.	Fu, E., Friedman, L., and Siegelman, H. W., Biochem. J. 179, 1 (1979).

79.	Rasmussen, R. D., Yokoyama, W. H., Blumenthal, S. G., Bergstrom, D. E., and Reubner, B. H., Anal. Biochem. 101, 66 (1980).

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