Rapid identification and quantitation of drugs in biofluids are helpful to the physician in managing patients with suspected drug intoxication. Higgins and O’Brien (1) noted that prior to 1960, drug overdoses usually consisted of a single drug. However, three years later they observed that multiple drug overdoses had risen to 13% (2). Law (3) reported that out of 240 proven drug misuse cases observed in Suburban Hospital, Bethesda, Maryland, over a four year period, 60% of the cases involved a single drug and 40% were multiple drug ingestions.