SpringerProtocols: Abstract: Clinical Uses of Microarrays in Cancer Research

Clinical Uses of Microarrays in Cancer Research

By: Carl Virtanen³, James Woodgett⁴

Abstract

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Perturbations in genes play a key role in the pathogenesis of cancer. Microarray-based technology is an ideal way in which to study the effects and interactions of multiple genes in cancer. There are many technologic challenges in running a microarray study, including annotation of genes likely to be involved, designing the appropriate experiment, and ensuring adequate quality assurance steps are implemented. Once data are normalized, they need to be analyzed; and for this, there are numerous software packages and approaches.

Affiliation(s): (3) University Health Network, Microarray Centre, Toronto Medical Discovery Tower, Toronto, Ontario, Canada
(4) Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

Book Title: Clinical Bioinformatics

Series: Methods in Molecular Medicine | Volume: 141 | Pub. Date: Dec-21-2007 | Page Range: 87-113 | DOI: 10.1007/978-1-60327-148-6_6

Subject: Bioinformatics

Key Words: cancer - microarray - annotation - experimental design - quality metrics - normalization - filtering - analysis

References

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