Springer Protocols: Abstract: Structural Basis for HLA-A2 Supertypes

Structural Basis for HLA-A2 Supertypes

By: Pandjassarame Kangueane³, Meena Kishore Sakharkar³

Abstract

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The human leukocyte antigen (HLA) alleles are extremely polymorphic among ethnic population, and the peptide-binding specificity varies for different alleles in a combinatorial manner. However, it has been suggested that majority of alleles can be covered within few HLA supertypes, where different members of a supertype bind similar peptides, yet exhibiting distinct repertoires. Nonetheless, the structural basis for HLA supertype-like function is not clearly known. Here, we use structural data to explain the molecular basis for HLA-A2 supertypes.

Affiliation(s): (3) School of Mechanical and Aerospace Engineering, NANYANG Technological University, Singapore

Book Title: Immunoinformatics: Predicting Immunogenicity In Silico

Series: Methods in Molecular Biology | Volume: 409 | Pub. Date: Jun-21-2007 | Page Range: 155-162 | DOI: 10.1007/978-1-60327-118-9_10

Subject: Immunology

Key Words: HLA - alleles - peptide - binding - supertypes - structural basis

References

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