SpringerProtocols: Abstract: The Application of Microfluidics in Biology

The Application of Microfluidics in Biology

By: David Holmes¹, Shady Gawad²

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Recent advances in the bio- and nanotechnologies have led to the development of novel microsystems for bio-particle separation and analysis. Microsystems are already revolutionising the way we do science and have led to the development of a number of ultrasensitive bioanalytical devices capable of analysing complex biological samples. These devices have application in a number of diverse areas such as pollution monitoring, clinical diagnostics, drug discovery and biohazard detection. In this chapter we give an overview of the physical principles governing the behaviour of fluids and particles at the micron scale, which are relevant to the operation of microfluidic devices. We briefly discuss some of the fabrication technologies used in the production of microfluidic systems and then present a number of examples of devices and applications relevant to the biological and life sciences.

Affiliation(s): (1) School of Electronics and Computer Science, Highfield, University of Southampton, Southampton, UK
(2) Swiss Federal Institute of Technology, Lausanne, Switzerland

Book Title: Microengineering in Biotechnology

Series: Methods in Molecular Biology | Volume: 583 | Pub. Date: Oct-01-2008 | Page Range: 55-80 | DOI: 10.1007/978-1-60327-106-6_2

Subject: Biotechnology

Key Words: Lab-on-a-chip - dielectrophoresis - microfluidics - MEMS - microTAS - microfabrication - BioMEMS - biochip - microsystems - optical traps - PDMS - soft lithography

References

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