Springer Protocols: Abstract: 1. Toxicogenomics and Classic Toxicology: How to Improve Prediction and Mechanistic Understanding of Human Toxicity

1. Toxicogenomics and Classic Toxicology: How to Improve Prediction and Mechanistic Understanding of Human Toxicity

By: Donna L. Mendrick⁴

Abstract

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The field of toxicogenomics has been advancing during the past decade or so since its origin. Most pharmaceutical companies are using it in one or more ways to improve their productivity and supplement their classic toxicology studies. Acceptance of toxicogenomics will continue to grow as regulatory concerns are addressed, proof of concept studies are disseminated more fully, and internal case studies show value for the use of this new technology in concert with classic testing.

Affiliation(s): (4) Department of Toxicogenomics, Gene Logic Inc., Gaithersburg, Maryland

Book Title: Essential Concepts in Toxicogenomics

Series: Methods in Molecular Biology | Volume: 460 | Pub. Date: Oct-01-2008 | Page Range: 1-22 | DOI: 10.1007/978-1-60327-048-9_1

Subject: Pharmacology/Toxicology

Key Words: hepatocytes - hepatotoxicity - idiosyncratic - phenotypic anchoring - toxicogenomics - toxicology

References

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