SpringerProtocols: Abstract: Animal Models of Hypertension

Animal Models of Hypertension

By: Brett M. Mitchell², Thomas Wallerath³, Ulrich Förstermann³

Abstract

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Hypertension affects approximately 25% of adults and is a major risk factor for cardiovascular disease. Although there are currently adequate therapeutic options for humans with hypertension, the molecular mechanisms underlying hypertension are still relatively unknown. The generation of hypertensive animal models provides an excellent modality to not only study the pathophysiology but also test innovative therapeutics. This chapter describes the detailed methods that utilize the drinking water of rats to develop models of nitric oxide synthase (NOS) inhibition-induced, guanosine triphosphate cyclohydrolase (GTPCH) inhibition-induced, and glucocorticoid-induced hypertension.

Affiliation(s): (2) Department of Internal Medicine Texas A&M Health Science, Center-College of Medicine Texas, USA
(3) Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany

Book Title: Vascular Biology Protocols

Series: Methods in Molecular Medicine | Volume: 139 | Pub. Date: Dec-01-2007 | Page Range: 105-111 | DOI: 10.1007/978-1-59745-571-8_6

Subject: Molecular Medicine

Key Words: Hypertension - Experimental - Nitric oxide synthase - GTP cyclohydrolase 1 - Tetrahydrobiopterin - Glucocorticoids

References

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