Springer Protocols: Abstract: Study Design: The Basics

Study Design: The Basics

By: Hyun Ja Lim², Raymond G. Hoffmann³

Abstract

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In biomedical research, meaningful conclusions can only be drawn based on data collected from a valid scientific design using appropriate statistical methods. Therefore, the selection of an appropriate study design is important in order to provide an unbiased and scientific evaluation of the research questions. In this chapter, the different kinds of experimental studies commonly used in biology and medicine are introduced. A brief survey of basic experimental study designs, randomization, blinding, possible biases, issues in data analysis, and interpretation of the study results are mainly provided.

Affiliation(s): (2) Department of Community Health and Epidemiology, University of Saskatchewan College of Medicine, Saskatoon, Saskatchewan, Canada
(3) Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI

Book Title: Topics in Biostatistics

Series: Methods in Molecular Biology | Volume: 404 | Pub. Date: Jul-06-2007 | Page Range: 1-17 | DOI: 10.1007/978-1-59745-530-5_1

Subject: Cell Biology

Key Words: As-received analysis - bias - blinding - block randomization - carryover effect - cluster design - complete randomization - compliance - crossover design - dropout - experimental study - exploratory analysis - factorial design - group allocation design - historically controlled study - intention-to-treat analysis - masking - per-protocol analysis - randomization - randomized controlled study - stratified randomization - subgroup analysis

References

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